Resident Evil 4

Resident Evil 4 reinvented survival horror by introducing the over-the-shoulder camera that every third-person shooter still uses today. The village siege, the lake monster, the Regenerators — every section introduces a new mechanic or threat that keeps you off balance. Shinji Mikami threw out everything that was not working and rebuilt the franchise from the ground up. It is the most influential action game of the 2000s.